Articles

Positive correlation of psoriasis vulgaris severity and HOMA-IR

Made Wardhana , Made Swastika Adiguna, Putu Ayu Diah Nareswari

Made Wardhana
Dermatology and Venereology Departement, Faculty of Medicine, Universitas Udayana/Sanglah General Hospital Denpasar, Bali, Indonesia. Email: wardhanamade@unud.ac.id

Made Swastika Adiguna
Dermatology and Venereology Departement, Faculty of Medicine, Universitas Udayana/Sanglah General Hospital Denpasar, Bali, Indonesia

Putu Ayu Diah Nareswari
Dermatology and Venereology Departement, Faculty of Medicine, Universitas Udayana/Sanglah General Hospital Denpasar, Bali, Indonesia Biomedical Master Science Study Program, Faculty of Medicine, Universitas Udayana
Online First: December 31, 2019 | Cite this Article
Wardhana, M., Adiguna, M., Nareswari, P. 2019. Positive correlation of psoriasis vulgaris severity and HOMA-IR. Bali Dermatology and Venereology Journal 2(1). DOI:10.15562/bdv.v2i1.18


Background: Psoriasis vulgaris is a chronic inflammatory skin disease that its aetiology is still not completely known. A chronic inflammation in psoriasis can cause organ dysfunctions. Elevation of proinflammatory cytokines gives rise to insulin resistance by inhibiting insulin and glucose transport mechanism signals. Insulin resistance is the underlying pathogenesis of metabolic syndrome.

Objective: This study aimed to undestand any correlation in the severity of psoriasis vulgaris with HOMA-IR.

Methods: A cross sectional research involving 35 subjects with psoriasis vulgaris and 15 subjects without who met the selection criteria. HOMA-IR is a formula used to measure insulin resistance which calculates the fasting insulin value in μU/ml x fasting glucose in mg/DL/405 taken from the blood veins of subjects. PASI score was used to determine psoriasis vulgaris severity.

Results: This study shows that the HOMA-IR median value was higher in psoriasis subject than the subjects without psoriasis (p<0.05). The correlaton analysis shows a moderate positive correlation between psoriasis vulgaris severity and HOMA-IR (r= 0.427; p<0.05). The prevalence ratio was 8.57, which means psoriasis vulgaris subjects were 8.57 times more likely to have HOMA-IR compared to those without psoriasis vulgaris (p<0.05; 95%CI: 1.26-58.1).

Conclusion: This study concludes that there is a moderate positive correlation between severity of psoriasis vulgaris and HOMA-IR values.

References

Azfar RS, Gelfand GM. Psoriasis and Metabolic Disease: Epidemiology and Pathophysiology. Curr Opin Rheumatol. 2008;20(4):416–422.

Adiguna MS, Wardhana M, Rahardjo FN. The positive correlation between psoriasis vulgaris severity degree with HbA1C level. Bali Dermatology and Venereology Journal. 2018;1(2):28-31.

Fitzgerald R, Sadlier M, Connoly M, Tobin AM. Psoriasis and Insulin Resistance: A Review. J Diabet Res & Clin Metab. 2014:1-5.

Fu Z, Gilbert ER, Liu D. Regulation of Insulin Synthesis and Secretion and Pancreatic Beta Cell Dysfunction in Diabetes. Curr Diabetes Rev. 2013;9(1):25-53.

Lestari, WAA. Resistensi Insulin: Definisi, Mekanisme dan Pemeriksaan Laboratoriumnya. Buku Ilmiah Clinical Pathology Update on SURAMADE 1. Surabaya. 2011. (Indonesian)

Napolitano M, Megna M, Monfrecola G. Insulin Resistance and Skin Diseases. The Scientific World Journal. 2015;p.1-11.

Coimbra S, Figueiredo A, Castro E, Rocha-Pereira P, Santos-Silva A. The role of cells and cytokines in the pathogenesis of psoriasis. International Journal of Dermatology. 2012;51:389-398.

Brauchli YB, Jick SS, Meier CR. Psoriasis and the risk of incident diabetes mellitus: a population-based study. Br J Dermatol. 2008; 159: 1331-7.

Sinniah B, Saraswathy DS, Prashant BS. Epidemiology of psoriasis in Malaysia: a hospital based study. Med J Malaysia. 2010;65(2):112-4.

Setyorini M, Triestianawati W, Wiryadi BE, Jacoeb TN. Proporsi sindrom metabolik pada pasien psoriasis vulgaris berdasarkan kriteria national cholesterol education program adult treatment panel III di Rumah Sakit Dr Cipto Mangunkusumo dan sebuah klinik swasta di Jakarta. MDVI. 2012;39(1): 2-9. (Indonesian)

Huerta C, Rivero E, Rodriguez LA. Incidence and risk factors for psoriasis in the general population. Arch Dermatol. 2007;143(12):1559-65.

Pujol RM, Puig L, Dauden E, Carazo S, Toribo J, Vanaclocha F, Yebenes M, Sabater E, Casado MA, Caloto MT. Mental health self-assessment in patient with moderate to severe psoriasis: An observational, multicenter study of 1164 patients in Spain (the VACAP study). 2013. Actas Dermatosifiliogr. 2013;100(10):1-7.

Gerkowicz A, Pietrzak A, Szepietowski JC, Radej S, Chodorowska G. Biochemical Markers of Psoriasis as a Metabolic Disease. Folia Histochemica et Cytobiologica. 2012;50(2):155–170.

Aruna C, Rao V, Ramanamurthy P, Rambabu P. Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based case control study from a tertiary care centre in Andhra Pradesh. NTR Univ Health Sci. 2016;5:13-6.


Article Views      : 9
PDF Downloads : 1