Buschke-Löwenstein tumour (BLT)/giant condyloma acuminatum (GCA): An immunopathogenesis insight

Paulus Mario Christopher , Hartono Kosim, Ratna Sari Wijaya, Silvi Suhardi, Linda Julianti Wijayadi

Paulus Mario Christopher
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia. Email:

Hartono Kosim
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia

Ratna Sari Wijaya
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia

Silvi Suhardi
Department of Dermatovenereology, Universitas Tarumanagara, Indonesia

Linda Julianti Wijayadi
Department of Dermatovenereology, Universitas Tarumanagara, Indonesia
Online First: June 01, 2020 | Cite this Article
Christopher, P., Kosim, H., Wijaya, R., Suhardi, S., Wijayadi, L. 2020. Buschke-Löwenstein tumour (BLT)/giant condyloma acuminatum (GCA): An immunopathogenesis insight. Bali Dermatology and Venereology Journal 3(1). DOI:10.15562/bdv.v%vi%i.27

Buschke Löwenstein tumor (BLT)/giant condyloma acuminatum is a rare variant of sexually transmitted infection caused by human papillomavirus (HPV) type 6 and 11. HPV has its viral factors that exist to avoid immune surveillance and control through 1) infecting only the basal layer of the epithelium, 2) downregulation of host immunity, 3) suppression of proinflammatory proteins essential for viral clearance. The incidence of BLT/GCA is estimated to be 0.1% in the general population, with males having 2.7 times increased risk than females. BLT/GCA is characterized by verrucous tumor or palpable cauliflower-likemass, exophytic growth, flesh-colored, and uneven surface. The definitive diagnosis of BLT/GCA is typical morphology along with histopathological examination, and/or viral serotyping. Treatment of BLT/GCA requires a multidisciplinary approach, determined based on age, the extent of the lesion, organ involvement, and organ location.


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