Beneficial effects of simvastatin in wound healing: review of the literature
Keywords:simvastatin, wound, wound healing
Wound healing is a normal biological complex and dynamic process of substituting injured or loss of continuity of cellular structures and tissue layers. Wound healing process consists of cellular components, humoral components, and molecular reaction that occurs in four different phases: haemostasis, inflammation, proliferation, and remodelling. These four phases must occur in the proper sequence and time frame to achieve successful wound healing. In recent years, research shows that Simvastatin have diverse pleiotropic effects that have been suggested to be useful to improve wound healing. Data derived from both animal and human studies showed that Simvastatin can accelerate the wound‐healing process. However, further high‐quality and evidence‐based studies are needed to address the appropriate dose, the best administration route, duration of treatment and to determine correlation between pleiotropic effects of Simvastatins and their probable clinical benefits.
Copyright (c) 2022 Chandra Wijaya Setiawan, Luh Made Mas Rusyati, Marrietta Sugiarti Sadeli
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