Beneficial effects of simvastatin in wound healing: review of the literature

Authors

  • Chandra Wijaya Setiawan Puri Medical Clinic, Badung, Bali
  • Luh Made Mas Rusyati Department of Dermatology and Venereology, Medical Faculty of Universitas Udayana/Sanglah General Hospital, Denpasar, Bali
  • Marrietta Sugiarti Sadeli Department of Dermatology and Venereology, Medical Faculty of Universitas Udayana/Sanglah General Hospital, Denpasar, Bali

DOI:

https://doi.org/10.15562/bdv.v5i1.81

Keywords:

simvastatin, wound, wound healing

Abstract

Wound healing is a normal biological complex and dynamic process of substituting injured or loss of continuity of cellular structures and tissue layers. Wound healing process consists of cellular components, humoral components, and molecular reaction that occurs in four different phases: haemostasis, inflammation, proliferation, and remodelling. These four phases must occur in the proper sequence and time frame to achieve successful wound healing. In recent years, research shows that Simvastatin have diverse pleiotropic effects that have been suggested to be useful to improve wound healing. Data derived from both animal and human studies showed that Simvastatin can accelerate the wound‐healing process. However, further high‐quality and evidence‐based studies are needed to address the appropriate dose, the best administration route, duration of treatment and to determine correlation between pleiotropic effects of Simvastatins and their probable clinical benefits.

Author Biographies

Chandra Wijaya Setiawan, Puri Medical Clinic, Badung, Bali

Puri Medical Clinic, Badung, Bali

Luh Made Mas Rusyati, Department of Dermatology and Venereology, Medical Faculty of Universitas Udayana/Sanglah General Hospital, Denpasar, Bali

Department of Dermatology and Venereology, Medical Faculty of Universitas Udayana/Sanglah General Hospital, Denpasar, Bali

Marrietta Sugiarti Sadeli, Department of Dermatology and Venereology, Medical Faculty of Universitas Udayana/Sanglah General Hospital, Denpasar, Bali

Department of Dermatology and Venereology, Medical Faculty of Universitas Udayana/Sanglah General Hospital, Denpasar, Bali

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Published

2022-06-30

Issue

Section

Review Article